custodiol cardioplegia solution

CUSTODIOL is the standard preservation solution for the rare and complex procedures of composite tissue procurement CUSTODIOL protects composite tissue against infl ammation7 Histopathologic scores of tissue sections of saline- CUSTODIOL- and UW-treated animals 2-30 hours of cold ischemia revealed the following results. Histidine-tryptophan-ketoglutarate HTK Bretschneiders or Custodiol is attractive for cardiac surgeons because it is administered as a single dose.

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Custodiol histidine-tryptophanketoglutarate HTK or Bretschneiders solution is an intracellular crystalloid cardioplegia solution that is currently in use for myocardial preservation during.

. Despite widespread use in Europe there is little data confirming its efficacy compared with conventional blood or crystalloid cardioplegia. 95 15 μmolg dry weight and plasma nitrite 11 03 ngml vs. The low sodium allows for increased osmotic space for better buffering.

Crystalloid cardioplegia is an aqueous ion solution similar to intracellular Custodiol HTK or. 15 mmolL sodium chloride 9 mmolL potassium chloride 4 mmolL magnesium chloride 18 mmolL histidine hydrochloride 180 mmolL histidine 2 mmolL tryptophan 30. A product approved by US FDA as a Medical Device and being a Multi Organ solution is also the solution of organ cleaning during cardiac surgery.

Preusse MD PhD Sigmund-Freud-Str. We hypothesized that a single administration of Bretschneider histidine-tryptophan-ketoglutarate HTK crystalloid solution Custodiol offers myocardial protection comparable with repeated tepid blood cardioplegia. This solution is essentially an intracellular-type solution and it is formulated as a low sodium and zero calcium solution.

The selection of a particular method depends mainly on the preferences and experience of a specific center or even surgeon. While UW provides lactobionate and raffinose Custodiol uses mannitol a very safe product. One liter of HTK solution Custodiol.

CUSTODIOL HTK Solution is indicated for perfusion and flushing of donor kidneys liver pancreas and heart prior to removal from the donor or immediately after removal from the donor. 86100 based on 1 PubMed citations. There is however one solution that is currently used clinically as an alternative to potassium-based cardioplegia and this is the HTK solution commercially available as Custodiol that was originally developed in the early 1960s in Germany.

Eligible recipients were at least 18 years of age and had to be on the heart-transplant waiting list at our center. As a crystalloid cardioplegia solution Custodiol HTK solution is considered an intracellular solution ie electrolyte concentrations similar to an intracellular concentration containing low concentrations of the electrolytes sodium calcium potassium and magnesium. On the other hand St.

Custodiol also known as histidine-tryptophan-α-ketoglutarate HTK Bretschneider solution is an attractive cardioplegic solution for longer cardiac operations because it is applied in a single dose and protects the myocardium for up to 4 h. A Single-Dose Hyperpolarizing Solution. A Single-Dose Hyperpolarizing Solution Claus J.

05 02 ngml were significantly. In addition the myocardial ATP content 128 10 μmolg dry weight vs. Even when advancement has came along the field of myocardial protection and cardioplegia solutions with the introduction of Bretschneider Histidine-Tryptophan-Ketoglutarate solution custodiol in 1970 which is given as a single dose and believed to be convenient simple to deliver and less time consuming.

Compared to Custodiol Custodiol-N is supplemented with the iron chelators deferoxamine and LK-614. Koehler Chemi Alsbach-Haenlien Germany contains the following components. The solution is left in the organ vasculature during hypothermic storage and transportation not for continuous perfusion to the recipient.

Of these we arrested the donor hearts before explant and before implant using blood cardioplegia and conditioning in 30 cases and in 13 cases we used standard Custodiol solution for cardioplegia standard care group. On the one hand Bretschneider Custodiol cardioplegia is an intracellular crystalloid cardioplegic solution with low concentration of calcium and sodium. Custodiol cardioplegia is attractive for minimally invasive cardiac surgery as a single dose provides a long period of myocardial protection.

Custodiol solution also called histidine-tryptophan-ketoglutarate HTK or Bretschneiders solution is a particular kind of long-acting intracellular crystalloid cardioplegia CCP that differs from other extracellular cardioplegic solutions because of its low sodium and potassium content that induce the diastolic cardiac arrest through an hyperpolarization of the myocyte plasma. The biochemical makeup of Custodiol HTK solution is practical and easier. Thomas 2 cardioplegia is an extracellular cardioplegic solution which is.

The use of Custodiol-N cardioplegic solution improved coronary blood flow 58 7 mlmin vs. Custodiol is an intracellular crystalloid cardioplegic solution used by some centres for myocardial protection in complex cardiac surgery and for organ preservation in transplant surgery. Presented at the Advanced Myocardial Protection Symposium San Antonio Texas October 9 2015.

Custodiol HTK Histidine Tryptophan Ketoglutarate Solution is used by leading Cardiac Surgery Centers as a cardioplegic solution worldwide. Although cardioplegia is used since the 70s of the last century debate on cardioprotection during cardio-surgical procedures is still actual. 25 D-53127 Bonn Germany.

201648P15P20 The Journal of ExtraCorporeal Technology Custodiol Cardioplegia. This article has been cited by other articles. Koehler Instrument custodiol cardioplegia solution Custodiol Cardioplegia Solution supplied by Koehler Instrument used in various techniques.

26 3 mlmin and effectively prevented cardiac dysfunction after cardiac arrest. Custodiol HTK histidine-tryptophan-ketoglutarate cardioplegia. Custodiol is a low viscosity solution with low levels of potassium low enough that Custodiol need not be flushed out of the organ prior to implantation and sodium.

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